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Its slippery gel-like properties provide lubrication that reduces friction, enabling joints, muscles and fascia to move freely without pain

Current therapeutic strategies of OA are largely concentrated in symptomatic management, such as oral non-steroidal anti-inflammatory drugs (NSAIDs) and intra-articular steroid injections, which only provide temporary relief 3,4

doi: 10.1007/s10989-022-10365-6 170 LitvackM

Regarding GI side effects, a notable proportion of patients experience nausea, vomiting, diarrhoea and constipation when taking GLP1RAs such as semaglutide and liraglutide

Numerous studies have demonstrated that elevated fatty acid levels activate the TLR-4 signaling in adipose tissue, urging the polarization of M to polarize from the anti-inflammatory M2 M into the pro-inflammatory M1 M (123)

Discontinuing tirzepatide (Mounjaro for type 2 diabetes, Zepbound for weight management) requires careful planning and medical supervision